Unsupported assumption in model of salt-sensitive hypertension

A mathematical model of salt-sensitive hypertension: the neurogenic hypothesis.

Salt sensitivity of arterial pressure (salt-sensitive hypertension) is a serious global health issue. The causes of salt-sensitive hypertension are extremely complex and mathematical models can elucidate potential mechanisms that are experimentally inaccessible. Until recently, the only mathematical model for long-term control of arterial pressure was the model of Guyton and Coleman; referred t...

Development of Salt-Sensitive Hypertension in Hydronephrosis

Salt Sensitive Hypertension and Orexin

Patients With Salt-Sensitive Hypertension

Twenty-two patients with normal plasma renln and essential hypertension were classified as "salt-sensitive" (SS) (n=9) or "non-salt-sensitive" (NSS) (n=13) from an increase in mean blood pressure with changes in sodium intake from 25 to 250 meq/day. With the high sodium diet, the SS patients gained more weight (/?<0.05), retained more sodium (/><0.05), and had a greater increase in cardiac outp...

Effect of salt on isoprostanes in salt-sensitive essential hypertension.

The controversy over beneficial versus harmful effects of salt on cardiovascular outcomes may be caused by different effects of salt on intermediate phenotypes of hypertension not characterized in epidemiological studies. Hence, we investigated acute effects of salt on oxidative stress in hypertensive subjects classified as salt sensitive (SS, n=14) or salt resistant (SR, n=13) by an inpatient ...